Facilities
Laboratory: We have access to ca. 2500 ft2 of newly renovated laboratory space. The laboratories contain twelve fume hoods and are equipped with facilities for benchtop chemical synthesis. Facilities for the synthesis of air- and moisture-sensitive compounds include nine dual-manifold Schlenk lines, and one ultra-low vacuum line. Other facilities for anaerobic synthesis available are: a PPT solvent purification system; two single-station and one dual-station MBraun gloveboxes equipped with freezers, vacuum facilities and cold wells. One of the gloveboxes is equipped for anaerobic spectroscopic analysis (IR spectroscopy) and electrochemical measurements.
Office space: Our group has access to a faculty office (213 ft2) and three student offices (590 ft2) that can accommodate up to 18 students. The offices are furnished with standard office furniture, computers, printers and most importantly, two coffee machines. A shared conference office area (209 ft2) is also available.
Indiana University Department of Chemistry Resources
X-ray Diffraction: The Indiana University Molecular Structure Center (IUMSC) has an international reputation for world-leading small molecule crystallography, and is used extensively by faculty and students in the IU Chemistry Department. The IUMSC has a full complement of single crystal and powder diffraction equipment used to characterize crystalline materials. Of greatest relevance to this proposal are the single-crystal X-ray diffractometers, which include a newly installed Bruker D8 Venture diffractometer and a Bruker Apex Kappa Duo diffractometer. Powder X-ray facilities, which are also critical for the analysis of the extended solids targeted in this proposal, include a Panalytical Empyrean diffractometer (with heating and atmosphere chambers) and a Scintag diffractometer. IUMSC maintains a crystallography classroom with computers and other teaching equipment, and provides access to proprietary and public domain crystallographic software, as well as common crystallographic databases including the IUMSC-developed Reciprocal Net database. The center also develops and maintains information technology tools for remote instrument access, fast data dissemination, and cyber collaboration to aid crystallographic experiments. The facility is staffed by two Ph.D. crystallographers (Drs. Nobu Yamamoto and Maren Pink), and one software engineer/informatics specialist (Anthony Parker). Access to the APS at Argonne National Laboratory (for data collection on extremely small or reactive crystals), and to the SNS (for neutron data collection) is periodically available and overseen by Dr. Pink.
Magnetic Resonance: The departmental NMR facility provides access to seven NMR spectrometers including a 500 MHz Varian Inova, two 400 MHz Varian Inova, and a 300 MHz Varian Gemini 2000, capable of performing variable temperature and multidimensional pulsed field gradient (PFG) NMR experiments. These instruments allow for the measurement of all common NMR-active nuclei (e.g. 1H, 13C, 19F, 31P etc.) and are available for walk-up use. These instruments will support the vast majority of the experimental work described in the research proposal. The most recent additions to the IU NMR facility are state-of-the-art 800 MHz and 600 MHz spectrometers with HCN cold probes. Three Ph.D. (in NMR) staff support the facility and provide training. The department also has a Bruker EMX X-band EPR spectrometer equipped with both low-temperature N2 and He dewars for variable temperature studies. A Ph.D. trained EPR technician oversees this facility. There is currently a bid in preparation for the procurement of a solid-state MAS NMR instrument which we will use.
Mass Spectrometry: The mass spectrometry facility (MSF) includes six mass spectrometers. It has a Thermo MAT-95XP double-focusing magnetic sector instrument with a wide range of ionization sources including FAB, EI, and positive- and negative-ion mode CI for accurate mass analyses of volatile and semi-volatile compounds. The MSF uses either of two Waters LCT TOFs equipped with either ESI or APCI sources to provide accurate mass data for non-volatile analytes. Research staff can use one of three walk-up mass spectrometers to facilitate their work. An Agilent 6890/5973 inert GC-MS is available for analyzing volatile and semi-volatile compounds. The GC-MS can perform either EI or CI, and the NIST-02 EI library is installed on the computer. An Agilent 1200/6130 LC-MS system may be used for walk-up analyses of non-volatile and air-sensitive compounds. The LC-MS has a multimode ESI/APCI source and can handle ions as large as 3000 m/z. A Bruker Autoflex III MALDI-TOF is also housed in the MSF and is available for analyzing polymers or compounds that are difficult to ionize by the previously mentioned methods. The MS laboratory is staffed by a full-time B.S. level technician with nearly 15 years of experience, and a director with a Ph.D. in biological mass spectrometry.
The College of Arts